In Vitro and In Vivo Characterization of Two C-11-Labeled PET Tracers for Vesicular Acetylcholine Transporter

PURPOSE: The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. Herein, two potent and selective (11)C-labeled VAChT inhibitors were evaluated in rodents and nonhuman primates for imaging VAChT in vivo. PROCEDURES: For both (−)-[(11)C]2 a...

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Udgivet i:Mol Imaging Biol
Main Authors: Padakanti, Prashanth K., Zhang, Xiang, Jin, Hongjun, Cui, Jinquan, Wang, Ruike, Li, Junfeng, Flores, Hubert P., Parsons, Stanley M., Perlmutter, Joel S., Tu, Zhude
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404702/
https://ncbi.nlm.nih.gov/pubmed/24865402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-014-0749-9
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