Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter

To identify suitable lipophilic compounds having high potency and selectivity for vesicular acetylcholine transporter (VAChT), a heteroaromatic ring or a phenyl group was introduced into the carbonyl-containing scaffold for VAChT ligands. Twenty new compounds with ALog D values between 0.53-3.2 were...

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Detalhes bibliográficos
Main Authors: Li, Junfeng, Zhang, Xiang, Zhang, Zhanbin, Padakanti, Prashanth K., Jin, Hongjun, Cui, Jinquan, Li, Aixiao, Zeng, Dexing, Rath, Nigam P., Flores, Hubert, Perlmutter, Joel S., Parsons, Stanley M., Tu, Zhude
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804129/
https://ncbi.nlm.nih.gov/pubmed/23802889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400664x
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