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In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter

The loss of cholinergic neurons and synapses relates to the severity of dementia in several neurodegenerative pathologies; and the vesicular acetylcholine transporter (VAChT) provides a reliable biomarker of cholinergic function. We recently characterized and (11)C-labeled a new VAChT inhibitor, (-)...

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Detalles Bibliográficos
Publicado en:Eur J Pharmacol
Main Authors: Liu, Hui, Jin, Hongjun, Li, Junfeng, Zhang, Xiang, Kaneshige, Kota, Parsons, Stanley M., Perlmutter, Joel S., Tu, Zhude
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369186/
https://ncbi.nlm.nih.gov/pubmed/25678250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2015.02.001
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