Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter

Vesicular acetylcholine transporter (VAChT) is a reliable biomarker for assessing the loss of cholinergic neurons in the brain that is associated with cognitive impairment of patients. 5-Hydrotetralin compound (±)-5-OH-VAT is potent (K(i) = 4.64 ± 0.32 nM) and selective for VAChT (>1800-fold and...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Yue, Xuyi, Luo, Zonghua, Liu, Hui, Kaneshige, Kota, Parsons, Stanley M., Perlmutter, Joel S., Tu, Zhude
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221475/
https://ncbi.nlm.nih.gov/pubmed/30274694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.09.030
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