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Exploration of new sulfur-containing analogues for imaging vesicular acetylcholine transporter in the brain
Sixteen new sulfur-containing compounds targeting vesicular acetylcholine transporter (VAChT) were synthesized and assessed for in vitro binding affinities. Enantiomers (-)-8 and (-)-14a displayed high binding affinities with K(i) values of 1.4 and 2.2 nM for human VAChT, moderate and high selectivi...
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| Udgivet i: | ChemMedChem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6422167/ https://ncbi.nlm.nih.gov/pubmed/30071131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800411 |
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