Exploration of new sulfur-containing analogues for imaging vesicular acetylcholine transporter in the brain

Sixteen new sulfur-containing compounds targeting vesicular acetylcholine transporter (VAChT) were synthesized and assessed for in vitro binding affinities. Enantiomers (-)-8 and (-)-14a displayed high binding affinities with K(i) values of 1.4 and 2.2 nM for human VAChT, moderate and high selectivi...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Luo, Zonghua, Liu, Hui, Jin, Hongjun, Gu, Jiwei, Yu, Yanbo, Kaneshige, Kota, Perlmutter, Joel S., Parsons, Stanley M., Tu, Zhude
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422167/
https://ncbi.nlm.nih.gov/pubmed/30071131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800411
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