Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock

INTRODUCTION: We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemorrhagic shock. METHODS: We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort...

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Vydáno v:Crit Care
Hlavní autoři: Vanzant, Erin L, Hilton, Rachael E, Lopez, Cecilia M, Zhang, Jianyi, Ungaro, Ricardo F, Gentile, Lori F, Szpila, Benjamin E, Maier, Ronald V, Cuschieri, Joseph, Bihorac, Azra, Leeuwenburgh, Christiaan, Moore, Frederick A, Baker, Henry V, Moldawer, Lyle L, Brakenridge, Scott C, Efron, Philip A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404112/
https://ncbi.nlm.nih.gov/pubmed/25880307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-015-0788-x
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