Aged Mice are Unable to Mount an Effective Myeloid Response to Sepsis

The elderly have increased morbidity and mortality following sepsis; however, the cause(s) remain unclear. We hypothesized that these poor outcomes are due in part to defects in innate immunity, rather than to an exaggerated early inflammatory response. Juvenile (6–12 weeks) or aged (20–24 months) m...

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Autori principali: Nacionales, Dina C., Gentile, Lori F., Vanzant, Erin, Lopez, M. Cecilia, Cuenca, Angela, Cuenca, Alex G., Ungaro, Ricardo, Li, Yi, Baslanti, Tezcan Ozrazgat, Bihorac, Azra, Moore, Frederick A., Baker, Henry V., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Efron, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884685/
https://ncbi.nlm.nih.gov/pubmed/24337739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302109
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