A BETTER UNDERSTANDING OF WHY MURINE MODELS OF TRAUMA DO NOT RECAPITULATE THE HUMAN SYNDROME

OBJECTIVE: Genomic analyses from blood leukocytes have concluded that mouse injury poorly reflects human trauma at the leukocyte transcriptome. Concerns have focused on the modest severity of murine injury models, differences in murine compared to human age, dissimilar circulating leukocyte populati...

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Foilsithe in:Crit Care Med
Main Authors: Gentile, Lori F., Nacionales, Dina C., Lopez, M. Cecilia, Vanzant, Erin, Cuenca, Angela, Cuenca, Alex G., Ungaro, Ricardo, Baslanti, Tezcan Ozrazgat, McKinley, Bruce A., Bihorac, Azra, Cuschieri, Joseph, Maier, Ronald V., Moore, Frederick A., Leeuwenburgh, Christiaan, Baker, Henry V., Moldawer, Lyle L., Efron, Philip A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283139/
https://ncbi.nlm.nih.gov/pubmed/24413577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000222
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