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The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation

The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crys...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Xu, Kai, Olsen, Olav, Tzvetkova-Robev, Dorothea, Tessier-Lavigne, Marc, Nikolov, Dimitar B.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403255/
https://ncbi.nlm.nih.gov/pubmed/25838500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.257675.114
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