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The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation
The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crys...
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| Publicado en: | Genes Dev |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403255/ https://ncbi.nlm.nih.gov/pubmed/25838500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.257675.114 |
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