Structures of Netrin-1 Bound to two Receptors Provide Insight into its Axon Guidance Mechanism

Netrins are secreted proteins that regulate axon guidance and neuronal migration. DCC is a well-established Netrin-1 receptor mediating attractive responses. We provide evidence that its close relative neogenin is also a functional Netrin-1 receptor that acts with DCC to mediate guidance in vivo. We...

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Udgivet i:Science
Main Authors: Xu, Kai, Wu, Zhuhao, Renier, Nicolas, Antipenko, Alexander, Tzvetkova-Robev, Dorothea, Xu, Yan, Minchenko, Maria, Nardi-Dei, Vincenzo, Rajashankar, Kanagalaghatta R., Himanen, Juha, Tessier-Lavigne, Marc, Nikolov, Dimitar B.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369087/
https://ncbi.nlm.nih.gov/pubmed/24876346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1255149
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