Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5

Eph receptor tyrosine kinases and their ephrin ligands mediate cell signaling during normal and oncogenic development. Eph signaling is initiated in a multistep process leading to the assembly of higher-order Eph/ephrin clusters that set off bidirectional signaling in interacting cells. Eph and ephr...

Full description

Saved in:
Bibliographic Details
Main Authors: Xu, Kai, Tzvetkova-Robev, Dorothea, Xu, Yan, Goldgur, Yehuda, Chan, Yee-Peng, Himanen, Juha P., Nikolov, Dimitar B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767517/
https://ncbi.nlm.nih.gov/pubmed/23959867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311000110
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items