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Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5

Eph receptor tyrosine kinases and their ephrin ligands mediate cell signaling during normal and oncogenic development. Eph signaling is initiated in a multistep process leading to the assembly of higher-order Eph/ephrin clusters that set off bidirectional signaling in interacting cells. Eph and ephr...

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Autors principals: Xu, Kai, Tzvetkova-Robev, Dorothea, Xu, Yan, Goldgur, Yehuda, Chan, Yee-Peng, Himanen, Juha P., Nikolov, Dimitar B.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767517/
https://ncbi.nlm.nih.gov/pubmed/23959867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311000110
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