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Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases
Mutations in the ultralong vascular protein von Willebrand factor (VWF) cause the common human bleeding disorder, von Willebrand disease (VWD). The A1 domain in VWF binds to glycoprotein Ibα (GPIbα) on platelets, in a reaction triggered, in part, by alterations in flow during bleeding. Gain-of-funct...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403213/ https://ncbi.nlm.nih.gov/pubmed/25810255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501689112 |
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