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Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding
Von Willebrand factor (VWF) is a large, multimeric plasma glycoprotein that critically mediates hemostasis at sites of vascular injury. Very large VWF multimers have the greatest thrombogenic activity, which is attenuated by cleavage in the A2 domain by the metalloproteinase ADAMTS13. ADAMTS13 prote...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309790/ https://ncbi.nlm.nih.gov/pubmed/22357761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121261109 |
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