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Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding
Von Willebrand factor (VWF) is a large, multimeric plasma glycoprotein that critically mediates hemostasis at sites of vascular injury. Very large VWF multimers have the greatest thrombogenic activity, which is attenuated by cleavage in the A2 domain by the metalloproteinase ADAMTS13. ADAMTS13 prote...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309790/ https://ncbi.nlm.nih.gov/pubmed/22357761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121261109 |
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