Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

The lengths of von Willebrand factor (VWF) concatamers correlate with hemostatic potency. After secretion in plasma, length is regulated by hydrodynamic shear force-dependent unfolding of the A2 domain, which is then cleaved by a specific protease. The 1.9-Å crystal structure of the A2 domain demons...

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Bibliographic Details
Main Authors: Zhang, Qing, Zhou, Yan-Feng, Zhang, Cheng-Zhong, Zhang, Xiaohui, Lu, Chafen, Springer, Timothy A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695068/
https://ncbi.nlm.nih.gov/pubmed/19470641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903679106
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