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Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor
The lengths of von Willebrand factor (VWF) concatamers correlate with hemostatic potency. After secretion in plasma, length is regulated by hydrodynamic shear force-dependent unfolding of the A2 domain, which is then cleaved by a specific protease. The 1.9-Å crystal structure of the A2 domain demons...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2695068/ https://ncbi.nlm.nih.gov/pubmed/19470641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903679106 |
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