Calcium modulates force sensing by the von Willebrand factor A2 domain

von Willebrand factor (VWF) multimers mediate primary adhesion and aggregation of platelets. VWF potency critically depends on multimer size, which is regulated by a feedback mechanism involving shear-induced unfolding of the VWF-A2 domain and cleavage by the metalloprotease ADAMTS-13. Here we repor...

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Bibliographic Details
Main Authors: Jakobi, Arjen J., Mashaghi, Alireza, Tans, Sander J., Huizinga, Eric G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144584/
https://ncbi.nlm.nih.gov/pubmed/21750539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1385
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