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Mechanisms by which von Willebrand Disease Mutations Destabilize the A2 Domain

von Willebrand Factor (VWF) is an ultralong, concatameric, and adhesive glycoprotein. On short time scales, adhesiveness for platelets is activated by elongation of VWF by altered hydrodynamics at sites of hemostasis. Over longer time scales, the length of VWF is regulated by ADAMTS13 (a disintegrin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Xu, Amy J., Springer, Timothy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585066/
https://ncbi.nlm.nih.gov/pubmed/23322777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422618
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