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Mechanisms by which von Willebrand Disease Mutations Destabilize the A2 Domain
von Willebrand Factor (VWF) is an ultralong, concatameric, and adhesive glycoprotein. On short time scales, adhesiveness for platelets is activated by elongation of VWF by altered hydrodynamics at sites of hemostasis. Over longer time scales, the length of VWF is regulated by ADAMTS13 (a disintegrin...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585066/ https://ncbi.nlm.nih.gov/pubmed/23322777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422618 |
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