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Mechanisms by which von Willebrand Disease Mutations Destabilize the A2 Domain
von Willebrand Factor (VWF) is an ultralong, concatameric, and adhesive glycoprotein. On short time scales, adhesiveness for platelets is activated by elongation of VWF by altered hydrodynamics at sites of hemostasis. Over longer time scales, the length of VWF is regulated by ADAMTS13 (a disintegrin...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585066/ https://ncbi.nlm.nih.gov/pubmed/23322777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422618 |
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