Quantitative modeling of transcription factor binding specificities using DNA shape

DNA binding specificities of transcription factors (TFs) are a key component of gene regulatory processes. Underlying mechanisms that explain the highly specific binding of TFs to their genomic target sites are poorly understood. A better understanding of TF−DNA binding requires the ability to quant...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhou, Tianyin, Shen, Ning, Yang, Lin, Abe, Namiko, Horton, John, Mann, Richard S., Bussemaker, Harmen J., Gordân, Raluca, Rohs, Remo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403198/
https://ncbi.nlm.nih.gov/pubmed/25775564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422023112
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