The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. Here, we found that increased neutral essential amino acid (NEAA) uptake was a critical component of erythr...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Chung, Jacky, Bauer, Daniel E., Ghamari, Alireza, Nizzi, Christopher P., Deck, Kathryn M., Kingsley, Paul D., Yien, Yvette Y., Huston, Nicholas C., Chen, Caiyong, Schultz, Iman J., Dalton, Arthur J., Wittig, Johannes G., Palis, James, Orkin, Stuart H., Lodish, Harvey F., Eisenstein, Richard S., Cantor, Alan B., Paw, Barry H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402725/
https://ncbi.nlm.nih.gov/pubmed/25872869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa5903
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