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Sleep Impairment and Reduced Interneuron Excitability in a Mouse Model of Dravet Syndrome
Dravet Syndrome (DS) is caused by heterozygous loss-of-function mutations in voltage-gated sodium channel Na(V)1.1. Our genetic mouse model of DS recapitulates its severe seizures and premature death. Sleep disturbance is common in DS, but its mechanism is unknown. Electroencephalographic studies re...
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| Veröffentlicht in: | Neurobiol Dis |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4402280/ https://ncbi.nlm.nih.gov/pubmed/25766678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.016 |
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