Sleep Impairment and Reduced Interneuron Excitability in a Mouse Model of Dravet Syndrome

Dravet Syndrome (DS) is caused by heterozygous loss-of-function mutations in voltage-gated sodium channel Na(V)1.1. Our genetic mouse model of DS recapitulates its severe seizures and premature death. Sleep disturbance is common in DS, but its mechanism is unknown. Electroencephalographic studies re...

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Pubblicato in:Neurobiol Dis
Autori principali: Kalume, Franck, Oakley, John C., Westenbroek, Ruth E., Gile, Jennifer, de la Iglesia, Horacio O., Scheuer, Todd, Catterall, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402280/
https://ncbi.nlm.nih.gov/pubmed/25766678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.016
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