Sleep Impairment and Reduced Interneuron Excitability in a Mouse Model of Dravet Syndrome

Dravet Syndrome (DS) is caused by heterozygous loss-of-function mutations in voltage-gated sodium channel Na(V)1.1. Our genetic mouse model of DS recapitulates its severe seizures and premature death. Sleep disturbance is common in DS, but its mechanism is unknown. Electroencephalographic studies re...

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Détails bibliographiques
Publié dans:Neurobiol Dis
Auteurs principaux: Kalume, Franck, Oakley, John C., Westenbroek, Ruth E., Gile, Jennifer, de la Iglesia, Horacio O., Scheuer, Todd, Catterall, William A.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402280/
https://ncbi.nlm.nih.gov/pubmed/25766678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.016
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