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Small Molecule-Triggered Cas9 Protein with Improved Genome-Editing Specificity
Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that are activated by the presence of a cell-permeable small molecule by inserting an evolved 4-hydroxytam...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4402137/ https://ncbi.nlm.nih.gov/pubmed/25848930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1793 |
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