Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates

Site-specific chemical conjugation of proteins can enhance their therapeutic and diagnostic utility but has seldom been applied to CRISPR-Cas9, which is a rapidly growing field with great therapeutic potential. The low efficiency of homology-directed repair remains a major hurdle in CRISPR-Cas9–medi...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Ling, Xinyu, Xie, Bingteng, Gao, Xiaoqin, Chang, Liying, Zheng, Wei, Chen, Heqi, Huang, Yujia, Tan, Linzhi, Li, Mo, Liu, Tao
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250679/
https://ncbi.nlm.nih.gov/pubmed/32494588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz0051
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