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Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates
Site-specific chemical conjugation of proteins can enhance their therapeutic and diagnostic utility but has seldom been applied to CRISPR-Cas9, which is a rapidly growing field with great therapeutic potential. The low efficiency of homology-directed repair remains a major hurdle in CRISPR-Cas9–medi...
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| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7250679/ https://ncbi.nlm.nih.gov/pubmed/32494588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz0051 |
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