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Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells
CRISPR/Cas9 is an efficient customizable nuclease to generate double-strand breaks (DSBs) in the genome. This process results in knockout of the targeted gene or knock-in of a specific DNA fragment at the targeted locus in the genome of various species. However, efficiency of knock-in mediated by ho...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5566437/ https://ncbi.nlm.nih.gov/pubmed/28827551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09306-x |
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