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The p53(R172H) Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression

Hepatocellular carcinoma is a highly deadly malignancy, accounting for approximately 800,000 deaths worldwide every year. Mutation of the p53 tumor suppressor gene is a common genetic change in HCC, present in 30% of cases. p53(R175H) (corresponding to p53(R172H) in mice) is a hotspot for mutation t...

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Podrobná bibliografie
Vydáno v:PLoS One
Hlavní autoři: Ahronian, Leanne G., Driscoll, David R., Klimstra, David S., Lewis, Brian C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401698/
https://ncbi.nlm.nih.gov/pubmed/25885474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123816
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