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Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
The tumour suppressor p53 is regulated primarily at the protein level. In normal tissues its levels are maintained at a very low level by the action of specific E3 ligases and the ubiquitin proteosome pathway. The mutant p53 protein contributes to transformation, metastasis and drug resistance. High...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627229/ https://ncbi.nlm.nih.gov/pubmed/26255629 |
| タグ: |
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