Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

The tumour suppressor p53 is regulated primarily at the protein level. In normal tissues its levels are maintained at a very low level by the action of specific E3 ligases and the ubiquitin proteosome pathway. The mutant p53 protein contributes to transformation, metastasis and drug resistance. High...

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Publicat a:Oncotarget
Autors principals: Goh, Amanda M., Xue, Yuezhen, Leushacke, Marc, Li, Ling, Wong, Julin S., Chiam, Poh Cheang, Rahmat, Siti Aishah Binte, Mann, Michael B., Mann, Karen M., Barker, Nick, Lozano, Guillermina, Terzian, Tamara, Lane, David P.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper: Pathology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627229/
https://ncbi.nlm.nih.gov/pubmed/26255629
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