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Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity
The p53 transcription factor modulates gene expression programs that induce cell cycle arrest, senescence, or apoptosis, thereby preventing tumorigenesis. However, the mechanisms by which these fates are selected are unclear. Our objective is to understand p53 target gene selection and, thus, enable...
Wedi'i Gadw mewn:
Prif Awduron: | , , , , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
National Academy of Sciences
2012
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277193/ https://ncbi.nlm.nih.gov/pubmed/22307631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114173109 |
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