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Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity

The p53 transcription factor modulates gene expression programs that induce cell cycle arrest, senescence, or apoptosis, thereby preventing tumorigenesis. However, the mechanisms by which these fates are selected are unclear. Our objective is to understand p53 target gene selection and, thus, enable...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Goh, Amanda M., Lim, Chin Yan, Chiam, Poh Cheang, Li, Ling, Mann, Michael B., Mann, Karen M., Menendez, Sergio, Lane, David P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277193/
https://ncbi.nlm.nih.gov/pubmed/22307631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114173109
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