PET radiotracer [(18)F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation

Cyclooxygenase-1 (COX-1), but not COX-2, is expressed at high levels in the early stages of human epithelial ovarian cancer where it seems to play a key role in cancer onset and progression. As a consequence, COX-1 is an ideal biomarker for early ovarian cancer detection. A series of novel fluorinat...

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Publicado no:Eur J Med Chem
Main Authors: Perrone, Maria Grazia, Malerba, Paola, Uddin, Jashim, Vitale, Paola, Panella, Andrea, Crews, Brenda C., Daniel, Cristina K., Ghebreselasie, Kebreab, Nickels, Mike, Tantawy, Mohammed N., Manning, H. Charles, Marnett, Lawrence J., Scilimati, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401082/
https://ncbi.nlm.nih.gov/pubmed/24832612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.04.074
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