SPAK-mediated NCC regulation in response to low-K(+) diet

The NaCl cotransporter (NCC) of the renal distal convoluted tubule is stimulated by low-K(+) diet by an unknown mechanism. Since recent work has shown that the STE20/SPS-1-related proline-alanine-rich protein kinase (SPAK) can function to stimulate NCC by phosphorylation of specific N-terminal sites...

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Udgivet i:Am J Physiol Renal Physiol
Main Authors: Wade, James B., Liu, Jie, Coleman, Richard, Grimm, P. Richard, Delpire, Eric, Welling, Paul A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398835/
https://ncbi.nlm.nih.gov/pubmed/25651563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00388.2014
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