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On the substrate recognition and negative regulation of SPAK, a kinase modulating Na(+)-K(+)-2Cl(−) cotransport activity
Threonines targeted by Ste20-related proline-alanine-rich kinase (SPAK) for phosphorylation have been identified in Na(+)-K(+)-2Cl(−) cotransporter type 1 (NKCC1), NKCC2, and Na(+)-Cl(−) cotransporter (NCC). However, what constitutes the substrate recognition of the kinase is still unknown. Using si...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944316/ https://ncbi.nlm.nih.gov/pubmed/20463172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00074.2010 |
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