Hepatitis C Virus Structural Proteins can Exacerbate or Ameliorate Acetaminophen-induced Liver Injury in Mice

Chronic Hepatitis C virus (HCV) infection pre-disposes patients to develop liver failure after acetaminophen (APAP) overdose. Mechanisms involved in this were explored using transgenic mice expressing the HCV structural proteins core, E1 and E2. Treatment of C57BL/6J mice with 200 mg/kg body weight...

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Gepubliceerd in:Arch Toxicol
Hoofdauteurs: Ramachandran, Anup, Lebofsky, Margitta, Yan, Hui-Min, Weinman, Steven A., Jaeschke, Hartmut
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398656/
https://ncbi.nlm.nih.gov/pubmed/25743375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1498-5
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