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Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining
Breakpoint junctions of the chromosomal translocations that occur in human cancers display hallmarks of nonhomologous end-joining (NHEJ). In mouse cells, translocations are suppressed by canonical NHEJ (c-NHEJ) components, which include DNA ligase IV (LIG4), and instead arise from alternative NHEJ (...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4398060/ https://ncbi.nlm.nih.gov/pubmed/25201414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.002 |
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