Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining

Breakpoint junctions of the chromosomal translocations that occur in human cancers display hallmarks of nonhomologous end-joining (NHEJ). In mouse cells, translocations are suppressed by canonical NHEJ (c-NHEJ) components, which include DNA ligase IV (LIG4), and instead arise from alternative NHEJ (...

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Udgivet i:Mol Cell
Main Authors: Ghezraoui, Hind, Piganeau, Marion, Renouf, Benjamin, Renaud, Jean-Baptiste, Sallmyr, Annahita, Ruis, Brian, Oh, Sehyun, Tomkinson, Alan, Hendrickson, Eric A., Giovannangeli, Carine, Jasin, Maria, Brunet, Erika
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398060/
https://ncbi.nlm.nih.gov/pubmed/25201414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.002
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