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Creating cancer translocations in human cells using Cas9 DSBs and nCas9 paired nicks

Recurrent chromosomal translocations are found in numerous of tumor types, often leading to the formation and expression of fusion genes with oncogenic potential. Creating chromosomal translocations at the relevant endogenous loci, rather than just ectopically expressing the fusion genes, opens new...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Renouf, Benjamin, Piganeau, Marion, Ghezraoui, Hind, Jasin, Maria, Brunet, Erika
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398311/
https://ncbi.nlm.nih.gov/pubmed/25398344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-801185-0.00012-X
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