Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks

DNA double-strand breaks (DSBs) are known to be powerful inducers of homologous recombination (HR), but single-strand breaks (nicks) have also been shown to trigger HR. Both DSB- and nick-induced HR ((nick)HR) are exploited in advanced genome-engineering approaches based on the bacterial RNA-guided...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Vriend, Lianne E.M., Prakash, Rohit, Chen, Chun-Chin, Vanoli, Fabio, Cavallo, Francesca, Zhang, Yu, Jasin, Maria, Krawczyk, Przemek M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914091/
https://ncbi.nlm.nih.gov/pubmed/27001513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw179
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