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Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks
DNA double-strand breaks (DSBs) are known to be powerful inducers of homologous recombination (HR), but single-strand breaks (nicks) have also been shown to trigger HR. Both DSB- and nick-induced HR ((nick)HR) are exploited in advanced genome-engineering approaches based on the bacterial RNA-guided...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914091/ https://ncbi.nlm.nih.gov/pubmed/27001513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw179 |
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