The Effects of Tissue-Nonspecific Alkaline Phosphatase Gene Therapy on Craniosynostosis and Craniofacial Morphology in the FGFR2(C342Y/+) Mouse Model of Crouzon Craniosynostosis

OBJECTIVES: Craniosynostosis, the premature fusion of cranial bones, has traditionally been described as a disease of increased bone mineralization. However, multiple mouse models of craniosynostosis display craniosynostosis simultaneously with diminished cranial bone volume and/or density. We propo...

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Veröffentlicht in:Orthod Craniofac Res
Hauptverfasser: Wang, E, Nam, HK, Liu, J, Hatch, NE
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396711/
https://ncbi.nlm.nih.gov/pubmed/25865549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ocr.12080
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