Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse

FGFR2c regulates many aspects of craniofacial and skeletal development. Mutations in the FGFR2 gene are causative of multiple forms of syndromic craniosynostosis, including Crouzon syndrome. Paradoxically, mouse studies have shown that the activation (Fgfr2c(C342Y); a mouse model for human Crouzon s...

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Detaylı Bibliyografya
Yayımlandı:Dis Model Mech
Asıl Yazarlar: Lee, Kevin K. L., Peskett, Emma, Quinn, Charlotte M., Aiello, Rosanna, Adeeva, Liliya, Moulding, Dale A., Stanier, Philip, Pauws, Erwin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262810/
https://ncbi.nlm.nih.gov/pubmed/30266836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.035311
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