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Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse

FGFR2c regulates many aspects of craniofacial and skeletal development. Mutations in the FGFR2 gene are causative of multiple forms of syndromic craniosynostosis, including Crouzon syndrome. Paradoxically, mouse studies have shown that the activation (Fgfr2c(C342Y); a mouse model for human Crouzon s...

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Publicat a:Dis Model Mech
Autors principals: Lee, Kevin K. L., Peskett, Emma, Quinn, Charlotte M., Aiello, Rosanna, Adeeva, Liliya, Moulding, Dale A., Stanier, Philip, Pauws, Erwin
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262810/
https://ncbi.nlm.nih.gov/pubmed/30266836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.035311
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