Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses

Effective therapy to prevent organ fibrosis, which is associated with more than half of all mortalities, remains elusive. Involvement of tumor suppressor ataxia telangiectasia mutated (ATM) in the TGF-β1 pathway related to renal fibrosis is largely unknown. ATM activation (pATM(Ser1981)) increased 4...

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Bibliographische Detailangaben
Veröffentlicht in:FASEB J
Hauptverfasser: Overstreet, Jessica M., Samarakoon, Rohan, Cardona-Grau, Diana, Goldschmeding, Roel, Higgins, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2015
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396616/
https://ncbi.nlm.nih.gov/pubmed/25480384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-262527
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