Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles

Extracellular ATP is a signal of tissue damage and induces macrophage responses that amplify inflammation and coagulation. Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reductase (TRXR) system and activates the inflammasome through endos...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Rothmeier, Andrea S., Marchese, Patrizia, Petrich, Brian G., Furlan-Freguia, Christian, Ginsberg, Mark H., Ruggeri, Zaverio M., Ruf, Wolfram
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396490/
https://ncbi.nlm.nih.gov/pubmed/25705884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79329
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