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Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles
Extracellular ATP is a signal of tissue damage and induces macrophage responses that amplify inflammation and coagulation. Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reductase (TRXR) system and activates the inflammasome through endos...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396490/ https://ncbi.nlm.nih.gov/pubmed/25705884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79329 |
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