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Tissue factor-PAR2 signaling promotes diet-induced obesity and adipose inflammation
Tissue factor (TF), the initiator of the coagulation cascade, mediates coagulation factor VIIa-dependent activation of protease activated receptor-2 (PAR2). Here we delineate an unexpected role for coagulation signaling in obesity and its complications. Mice lacking PAR2 (F2rl1) or the cytoplasmic d...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210891/ https://ncbi.nlm.nih.gov/pubmed/22019885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2461 |
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