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Effect of Protein Binding on Unbound Atazanavir and Darunavir Cerebrospinal Fluid Concentrations

HIV-1 protease inhibitors (PIs) exhibit different protein binding affinities and achieve variable plasma and tissue concentrations. Degree of plasma protein binding may impact central nervous system penetration. This cross-sectional study assessed cerebrospinal fluid (CSF) unbound PI concentrations,...

詳細記述

保存先:
書誌詳細
出版年:J Clin Pharmacol
主要な著者: Delille, Cecile A., Pruett, Sarah T., Marconi, Vincent C., Lennox, Jeffrey L., Armstrong, Wendy S., Arrendale, Richard F., Sheth, Anandi N., Easley, Kirk A., Acosta, Edward P., Vunnava, Aswani, Ofotokun, Ighovwerha
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396178/
https://ncbi.nlm.nih.gov/pubmed/24691856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.298
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