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Effect of Protein Binding on Unbound Atazanavir and Darunavir Cerebrospinal Fluid Concentrations
HIV-1 protease inhibitors (PIs) exhibit different protein binding affinities and achieve variable plasma and tissue concentrations. Degree of plasma protein binding may impact central nervous system penetration. This cross-sectional study assessed cerebrospinal fluid (CSF) unbound PI concentrations,...
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| 出版年: | J Clin Pharmacol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396178/ https://ncbi.nlm.nih.gov/pubmed/24691856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.298 |
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