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T cell RANKL/OPG imbalance is associated with HIV-induced bone loss in patients with higher CD4(+) T cell counts

OBJECTIVE: Higher incidence of osteopenia and osteoporosis underlie increased rates of fragility fracture in HIV infection. B cells are a major source of Osteoprotegerin (OPG), an inhibitor of the key osteoclastogenic cytokine Receptor Activator of Nuclear Factor-κB Ligand (RANKL). We previously sho...

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Detalhes bibliográficos
Publicado no:AIDS
Main Authors: TITANJI, Kehmia, VUNNAVA, Aswani, FOSTER, Antonina, SHETH, Anandi N., LENNOX, Jeffrey L., KNEZEVIC, Andrea, SHENVI, Neeta, EASLEY, Kirk A., OFOTOKUN, Ighovwerha, WEITZMANN, M. Neale
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869175/
https://ncbi.nlm.nih.gov/pubmed/29424771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000001764
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