Effect of Protein Binding on Unbound Atazanavir and Darunavir Cerebrospinal Fluid Concentrations

HIV-1 protease inhibitors (PIs) exhibit different protein binding affinities and achieve variable plasma and tissue concentrations. Degree of plasma protein binding may impact central nervous system penetration. This cross-sectional study assessed cerebrospinal fluid (CSF) unbound PI concentrations,...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Pharmacol
Auteurs principaux: Delille, Cecile A., Pruett, Sarah T., Marconi, Vincent C., Lennox, Jeffrey L., Armstrong, Wendy S., Arrendale, Richard F., Sheth, Anandi N., Easley, Kirk A., Acosta, Edward P., Vunnava, Aswani, Ofotokun, Ighovwerha
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396178/
https://ncbi.nlm.nih.gov/pubmed/24691856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.298
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