Effect of Protein Binding on Unbound Atazanavir and Darunavir Cerebrospinal Fluid Concentrations

HIV-1 protease inhibitors (PIs) exhibit different protein binding affinities and achieve variable plasma and tissue concentrations. Degree of plasma protein binding may impact central nervous system penetration. This cross-sectional study assessed cerebrospinal fluid (CSF) unbound PI concentrations,...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Clin Pharmacol
Main Authors: Delille, Cecile A., Pruett, Sarah T., Marconi, Vincent C., Lennox, Jeffrey L., Armstrong, Wendy S., Arrendale, Richard F., Sheth, Anandi N., Easley, Kirk A., Acosta, Edward P., Vunnava, Aswani, Ofotokun, Ighovwerha
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396178/
https://ncbi.nlm.nih.gov/pubmed/24691856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.298
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares