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Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation
Tumor heterogeneity is of growing importance in the treatment of cancers. Mutational hot spots are prime locations for determining number and proportions of low variant allele frequency (VAF) tumor subclones by next generation sequencing. Low VAF detection is complicated by poor mapping efficiency i...
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| Publicado no: | Genome Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4395979/ https://ncbi.nlm.nih.gov/pubmed/25874000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0147-1 |
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