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Ultradeep Sequencing of a Human Ultraconserved Region Reveals Somatic and Constitutional Genomic Instability

Early detection of cancer-associated genomic instability is crucial, particularly in tumour types in which this instability represents the essential underlying mechanism of tumourigenesis. Currently used methods require the presence of already established neoplastic cells because they only detect cl...

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Detalhes bibliográficos
Main Authors: De Grassi, Anna, Segala, Cinzia, Iannelli, Fabio, Volorio, Sara, Bertario, Lucio, Radice, Paolo, Bernard, Loris, Ciccarelli, Francesca D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794366/
https://ncbi.nlm.nih.gov/pubmed/20052272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000275
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