Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Changes in gene dosage are a major driver of cancer, engineered from a finite, but increasingly well annotated, repertoire of mutational mechanisms(1). This can potentially generate correlated copy number alterations across hundreds of linked genes, as exemplified by the 2% of childhood acute lympho...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Li, Yilong, Schwab, Claire, Ryan, Sarra, Papaemmanuil, Elli, Robinson, Hazel M., Jacobs, Patricia, Moorman, Anthony V., Dyer, Sara, Borrow, Julian, Griffiths, Mike, Heerema, Nyla A., Carroll, Andrew J., Talley, Polly, Bown, Nick, Telford, Nick, Ross, Fiona M., Gaunt, Lorraine, McNally, Richard J. Q., Young, Bryan D., Sinclair, Paul, Rand, Vikki, Teixeira, Manuel R., Joseph, Olivia, Robinson, Ben, Maddison, Mark, Dastugue, Nicole, Vandenberghe, Peter, Stephens, Philip J., Cheng, Jiqiu, Van Loo, Peter, Stratton, Michael R., Campbell, Peter J., Harrison, Christine J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976272/
https://ncbi.nlm.nih.gov/pubmed/24670643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13115
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