Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Changes in gene dosage are a major driver of cancer, engineered from a finite, but increasingly well annotated, repertoire of mutational mechanisms(1). This can potentially generate correlated copy number alterations across hundreds of linked genes, as exemplified by the 2% of childhood acute lympho...

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Detalhes bibliográficos
Main Authors: Li, Yilong, Schwab, Claire, Ryan, Sarra, Papaemmanuil, Elli, Robinson, Hazel M., Jacobs, Patricia, Moorman, Anthony V., Dyer, Sara, Borrow, Julian, Griffiths, Mike, Heerema, Nyla A., Carroll, Andrew J., Talley, Polly, Bown, Nick, Telford, Nick, Ross, Fiona M., Gaunt, Lorraine, McNally, Richard J. Q., Young, Bryan D., Sinclair, Paul, Rand, Vikki, Teixeira, Manuel R., Joseph, Olivia, Robinson, Ben, Maddison, Mark, Dastugue, Nicole, Vandenberghe, Peter, Stephens, Philip J., Cheng, Jiqiu, Van Loo, Peter, Stratton, Michael R., Campbell, Peter J., Harrison, Christine J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976272/
https://ncbi.nlm.nih.gov/pubmed/24670643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13115
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