Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Changes in gene dosage are a major driver of cancer, engineered from a finite, but increasingly well annotated, repertoire of mutational mechanisms(1). This can potentially generate correlated copy number alterations across hundreds of linked genes, as exemplified by the 2% of childhood acute lympho...

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Bibliografische gegevens
Hoofdauteurs: Li, Yilong, Schwab, Claire, Ryan, Sarra, Papaemmanuil, Elli, Robinson, Hazel M., Jacobs, Patricia, Moorman, Anthony V., Dyer, Sara, Borrow, Julian, Griffiths, Mike, Heerema, Nyla A., Carroll, Andrew J., Talley, Polly, Bown, Nick, Telford, Nick, Ross, Fiona M., Gaunt, Lorraine, McNally, Richard J. Q., Young, Bryan D., Sinclair, Paul, Rand, Vikki, Teixeira, Manuel R., Joseph, Olivia, Robinson, Ben, Maddison, Mark, Dastugue, Nicole, Vandenberghe, Peter, Stephens, Philip J., Cheng, Jiqiu, Van Loo, Peter, Stratton, Michael R., Campbell, Peter J., Harrison, Christine J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976272/
https://ncbi.nlm.nih.gov/pubmed/24670643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13115
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